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It seems there is a close interplay between estrogen levels and GH secretion and prevailing estrogen concentrations may modulate both GH secretion and action (Leung et al., 2004)

Exclusion criteria for both the FEP and healthy control groups involved meeting criteria for a substance use disorder in the past year according to DSM-5 [36] criteria (this was based on self-report for controls, and in addition clinical assessment and urine drug screening done at the point of clinical assessment in suspected cases for patients), having a history of a major head injury (leading to a significant period of unconsciousness or seizures), having a significant, uncontrolled medical illness, or having any contraindications to undergoing MRI

Although limited research has examined antioxidant supplementation in aged horses, chronic low-grade inflammation, termed inflammaging, is well documented in this population (Adams et al., 2008

None of that makes them useless