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Compared to 108 control subjects without evidence of dementia, subjects with dementia of Alzheimer's type and confirmed Alzheimer's disease had higher blood levels of homocysteine and lower blood levels of folate and vitamin B 12
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Whether this potential mechanism reflects glial or neuronal co-transmission is presently unclear, but potential VMAT2-dependent Put-GABA synthesis and release by monoaminergic neurons under extended waking/high nitrogen conditions is a particularly exciting possibility
Moreover, oral BPC-157 has a low bioavailability and does not usually have a direct effect on tissues outside the gastrointestinal tract (e.g., tendons and nerves)
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