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Specific protein 1 (SP1)-mediated upregulation of PRDX6 expression also prevented iron overload by regulating iron metabolism, restoring SLC7A11 activity and GSH activity, and further promoting the increase in GPX4 expression to prevent ferroptosis-associated DN [238]

Anti-inflammatory and cytoprotective effects were noted in a systematic review in 2024 and are also said to include attenuating oxidative stress and reinforcing gastrointestinal mucosal barriers during experimental injury

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