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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

doi: 10.1016/0014-2999(90)90204-J

The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice

They complement each other, and many researchers use them in combination, but each has value on its own depending on the primary sleep issue being addressed