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Whether you or someone close to you has been touched by the struggle of pernicious anaemia, understanding its nuances is the key to unlocking better health outcomes

Excessive release of glutamate and its binding with NMDA, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), or kainite (KA) receptors promotes excitotoxicity cell injury with a consequent activation of many molecular pathways, resulting in intracellular calcium (Ca 2+ ) overload 90,91 , reactive oxygen species (ROS) production, mPT, and cell swelling with brain edema 92

Immune function

In addition to acting on opioid receptors, opioid peptides have also been shown to interact with toll-like receptors (TLR), particularly TLR4 (Eidson and Murphy 2013