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However, more research is needed to fully understand its effects and potential therapeutic applications.

doi: 10.3389/fmicb.2025.1639438 Received 02 June 2025 Revised 17 November 2025 Accepted 17 November 2025 Published 12 February 2026 Volume 16 - 2025 Edited by Xue-Gong Li, Chinese Academy of Sciences (CAS), China Reviewed by Emmanuel Oliver Fenibo, Hensard University, Nigeria Judy Malas, University of Illinois Chicago, United States Alef Dos Santos, Ume University, Sweden Updates Copyright 2026 del Moral, Siggs, Macey, Fox-Powell, Pearson and Olsson-Francis

"So, we need to be more involved in their choices when it looks like their risks of bad outcomes are higher by taking them." People with low-functioning kidneys often can't take common over-the-counter pain relievers, such as ibuprofen, because these medications can further harm the kidneys