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The pre-dosed oral format removes the handling steps required by other presentations and simplifies study design wherever an oral route of exposure is preferred

Since naturally occurring inhibitors of melanogenesis usually garner more attention compared with chemically synthesized compounds due to the cosmetic demands of consumers, the present review focuses on natural compounds that have been documented to exhibit skin-whitening effects through the inhibition of TYR activity

Once opened, exposure to air/oxygen increases oxidation risk, and using sterile technique (especially for reconstituted solution) is essential

More animal and human studies should be carried out to confirm these changes and elucidate the potential connection between protein expression and related outcomes after riboflavin deficiency