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[DOI] [PubMed] [Google Scholar] 73.Qajari N.M., Khonakdar-Tarsi A

Neelakantan et al., Biochemical Pharmacology, 2018, gave diet-induced obese mice the compound and reported it significantly reduced body weight and white adipose mass, decreased adipocyte size, with food intake unchanged (PMID 29155147) [3]

These include immune-mediated cytokine release, hormonal modulation through the hypothalamicpituitaryadrenal (HPA) axis, and neural pathways involving both the enteric nervous system (ENS) and the vagus nerve (Guzzetta et al., 2022

While a sulfur containing amino acid deficiency in konzo-prone regions has been speculated for several decades 11 , this is the first quantitative evidence that demonstrates a cystine deficiency within these populations, regardless of disease status