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In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

Monitoring for signs of B12 deficiency remains important, particularly if Mounjaro-related side effects lead to prolonged reduced food intake or vomiting

In addition, other mobility devices such as walkers, cane and crutches can be difficult to use on a ramp or on stairs