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Nitrosylation of cysteine 10 of TTR-V30M promotes dsNNTTR formation The requirement of an oxidative agent is implicated in the formation of dsNNTTR, and we have previously shown that it can be obtained using both the oxidizing agent diamide as well as via disulfide shuffling of disulfide conjugated adducts [22]

N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans