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A Phase I safety trial evaluating the administration of synthetic T4 at massive doses ranging from 42mg to 1260mg over 14 days demonstrated excellent tolerability with no severe toxicities or serious adverse events reported in healthy adults

In all subgroups measured, the ADS-5102 group showed a greater benefit than placebo, with the treatment effect independent of baseline dyskinesia severity, as evidenced by the overlap of 95% CIs for 12-week changes in UDysRS scores in different patient subgroups

The National Academies of Sciences, Engineering, and Medicine recommend: People ages 14 and older get 2.4 mcg of B12 per day Pregnant individuals get 2.6 mcg of B12 per day Breastfeeding individuals get 2.8 mcg of B12 per day There hasn't been a tolerable upper intake level set for B12

10.1007/s00210-023-02672-6 58 LuW.ChuP.TangA.SiL.FangD