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Test to Diagnose Mesothelioma Physical examination and medical history: Checks for lumps, fluid buildup and asbestos exposure history Imaging tests: Chest X-rays, CT scans, MRIs and PET scans reveal abnormalities and tumor locations Blood tests: Detect biomarkers like SMRP, fibulin-3 and osteopontin (elevated levels suggest mesothelioma) Biopsy: The only definitive diagnostic test

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