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Emerging evidence supports a syndromic view: RIF/RPL often reflect convergent endometrial dysfunction in which decidualization defects, immune dysregulation, and stromal-epithelial crosstalk abnormalities co-occur [297, 448]

Therefore, more research is needed to investigate the links between kidney disease, changes in cerebral structure, and cognitive performance in diverse racial groups (122)

Another small, randomized, double-blind trial in 93 individuals with low vitamin D status found no additional benefit of B-vitamin supplementation (50 mg/day of vitamin B6, 0.5 mg/day of folic acid, and 0.5 mg/day of vitamin B 12 ) on markers of bone health over a one-year period beyond that associated with vitamin D and calcium supplementation