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[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Christina A., Ashok K., Packialakshmi M., Tobin G., Preethi J., Murugesh N

While classical gene mutations are region-limited, epimutations often occur early in cancer development and have a genome-wide impact, boosting on the one hand the expression of cell survival genes or proto-oncogenes and deactivating on the other hand tumor suppressor genes (TSGs), DNA repair mechanisms as well as cell division brakes, thus leading to carcinogenesis (Esteller, 2008

The time for normal skin to scab after transplantation has been reduced from 10-14 days to 5 days.