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Regulatory role of metallothionein-1/2 on development of sex differences in a high-fat diet-induced obesity

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The mechanism and timeline are the same as for male patients, with some adjustments in the protocol for patients in perimenopause or menopause where hormonal changes affect collagen synthesis and healing rates

This fragment oligomerizes and inserts into the plasma membrane, forming pores that disrupt membrane integrity, increase ion influx, and lead to cell swelling and eventual rupture (Kovacs and Miao, 2017)