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This has even been achieved in lower eukaryotes such as Saccharomyces cerevisiae , where a significant resistance to chlorambucil and doxorubicin (eight- and 16-fold, respectively) was reported in cells transfected with mammalian GST isozymes (Black et al ., 1990)

However, when used as a long-term strategy, it often fails to resolve underlying drivers of painand may introduce new problems over time

The gyrB gene was used to normalize the expression in S

1 Introduction Liver disease represents a major global health challenge with diverse etiologies, including viral infections (hepatitis B and C), alcohol abuse, metabolic disorders (Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD), drug- and toxin-induced injuries, and autoimmune hepatitis