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Typically, intramuscular treatment for dietary vitamin B12 deficiency begins with a loading dose followed by maintenance therapy, contrasting with the steady daily doses used in oral treatment due to limited passive absorption

Other than GI-related side effects, patients on semaglutide also report serious side effects, such as kidney problems, pancreatitis, gallbladder disease, hypoglycemia (low blood sugar), and severe allergic reactions

Oral administration is the most logical route for gut-focused applications, since the peptide is uniquely stable in gastric juice

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