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Weight management A 2018 meta-analysis of randomized, placebo-controlled trials found that lipoic acid supplementation in those with high body mass index (BMI) resulted in significant, yet modest, reductions in weight (9 studies) and BMI (11 studies) in the absence of caloric restriction (except in one study) (105)

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Future studies should focus on whether these effects are long lasting with a deeper assessment of how they may correlate clinically, given that cognition is impaired in 4070% of patients with MS ( There are limited studies evaluating cerebral glucose metabolism in relation to cognitive impairment in MS patients

The cycle planning guide discusses how to structure protocols for different goals