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Part of what's so fascinating about this drug is that it's getting rid of the fungus and mold, it's improving gut integrity I've had multiple families where their kids have had 2 or 3 years of chronic constipation or diarrhea, and then literally 3 or 4 weeks later, "Oh my God, this is the first normal poop she's had her entire life." So it improves the gut, it improves the microbiome, it gets rid of the fungus, and simultaneously it's actually influencing multiple cascades of immunity within the systemic and nervous system all at the same time, which to me is so fascinating to reflect on
Occupancy stays low, but each engaged receptor keeps sending its main message longer than it would under a balanced signal (cAMP bias with low receptor internalization). In a head-to-head trial against liraglutide, tirzepatide reduced measured food intake and craving more despite lower GLP-1 occupancy. The effect lowers the drive to eat rather than increasing restraint
Patients should always inform their healthcare provider about: A complete medical review helps reduce the risk of unexpected interactions and ensures treatment decisions are based on an individuals overall health profile
The last approach that is rarely used by us nowadays is the interlaminar approach, which places the injection directly into the central canal between two vertebrae
