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Description

Liver biopsies obtained from both NASH patients and rodent NAFLD models demonstrated defective mitochondrial respiratory chain function together with altered mitochondrial structure, presented as enlarged mitochondria, rounded cristae and loss of the typical dense mitochondrial granules, as well as an epigenetic modification on mitochondrial DNA [65, 66]

Ann N YAcad Sci 2004

Giffard, R

In our recent studies, we have identified a different inhibition mechanism of TGR in which an inhibitor binds non-covalently at the so-called doorstop pocket interfering with enzyme function 33,34