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Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: A drug discovery effort against alzheimer's disease

Hypoxia then stabilizes HIF-1 and upregulates REST, which suppresses GCLM/GPX4 expression and enhances ACSL4-dependent lipid peroxidationdirectly amplifying ferroptosiswhile also promoting the release of hypoxic extracellular vesicles (EVs) that propagate tubular ferroptosis in a paracrine manner

GRF (1-29) itself was found to suffer from rapid metabolic clearance, leading to the synthesis of analogues with substituted amino acids more resistant to enzymatic cleavage

Nature microbiology 2022