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These changes are associated with faster development of cataracts in knockout mice compared to wild-type mice

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Fusion of the inner membrane is regulated by optic atrophy 1 (OPA1), a dynamin-like GTPase that facilitates membrane tethering, lipid mixing, and cristae organization, resulting in elongated and functionally integrated mitochondrial networks ( Fission and fusion operate in a coordinated and interdependent manner

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