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FIGURE 2 Apoptosis and ATG are processes altered in cancer cells that show critical metabolic transformations associated with enhanced cellular stress

2020;229(1):e13443

Pharmaceutics 15 , 2599 (2023)

Upon activation by MenSCs, increased enrichment of 5-hmC and 5-mC in key enhancer regions leads to downregulation of the PI3K/AKT and RAF/ERK pathways, thereby inhibiting HCC cell proliferation and promoting apoptosis