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The mammalian blood-testis barrier: its biology and regulation

The reaction from NR to NAM appears to be saturable and rate-limiting.[25] This would be expected to theoretically result in a slower rate of absorption and incorporation into NAD + when NR is taken as a supplement compared to NA or NAM, which was supported by a comparative study that measured liver NAD + after NA, NAM, and NR.[26] NAM can be used locally in the gut (for NAD biosynthesis) or absorbed into circulation

Proper injection technique and site rotation can minimize these effects

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