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Also, overexpression of heme oxygenase-1, a stress-induced enzyme that produces endogenous carbon monoxide, has been found to protect dopaminergic neurons from neurotoxicity in an animal model of Parkinsons. In addition, nicotine, a major constituent of cigarette smoke, has been found to be ineffective at slowing the diseases progression in a recently reported clinical trial

McCormack V, Peto J, et al

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Nevertheless, the ROS generated by separate exposures of bronchial and alveolar mucosa models to flavor 2 is consistent with transcript expression of oxidative stress markers