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263,264 Furthermore, ALDH1A3-induced PKM2 tetramerization reprograms glycometabolism and increases lactate production in GSCs, leading to lactylation of XRCC1 at K247

For example, Lys48-linked polyubiquitin chains usually target proteins for degradation (Husnjak et al., 2008), whereas Lys63-linked polyubiquitination is involved in regulation of NFB signaling (Laplantine et al., 2009), Lys27-linked polyubiquitin chains are important for mitophagy (Geisler et al., 2010), and Lys11-linked polyubiquitination is implicated in cell cycle regulation (Grabbe et al., 2011

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