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It was found that semaglutide, a long-acting GLP-1RA, could improve symptoms caused by sepsis, reduce body temperature, and decrease the bacterial load in multiple organs, along with the levels of inflammatory factors in plasma and lungs

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Specially, the pro-survival pathway PI3K/Akt directly affects the expression of key ferroptosis-related proteins, such as GPX4, SLC7A11, Nrf2, and ACSL4, thereby affecting ferroptotic metabolism (Wang et al, 2024a)

Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo