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Seleno-glutathione peroxidase mimic ebselen (PZ51)-protected endothelial and vascular system of spontaneous hypertensive rats (SHRsp) prone to stroke during pregnancy chronic hypertension [80]

561 Currently, combination therapies involving VIR-2218 are in multiple Phase II trials for HBV patients, and results are eagerly awaited (NCT04856085 and NCT04412863)

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PURINE CATABOLISM In addition to GSH redox coupling mechanism and NO signaling, purine catabolism ( Figure 2 ) may be a previously unappreciated component of the homeostatic response of mitochondria to oxidant stress and may play a critical role in slowing progressive mitochondrial dysfunction in certain disease states (Kristal et al., 1999)