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This work was supported by the National Natural Science Foundation of China (32402644), the General Program of Liaoning Provincial Science and Technology Joint Fund (2024-MSLH-161) and the Youth Project of the Department of Education of Liaoning Province (jytqn2023439)

Advanced Applications Longer action: Supports sustained GH exposure with fewer fluctuations

Label the vial clearly with the actual concentration and maintain detailed records showing the discrepancy and corrected volumes to preserve data integrity across your study timeline

Dosing Comparison# Retatrutide Dosing# Based on Phase 2 trial data: Route : Once-weekly subcutaneous injection Dose range studied : 0.5 mg to 12 mg weekly Optimal dose : 12 mg weekly showed maximum efficacy in Phase 2 Titration : Gradual dose escalation over several weeks to manage GI tolerability Tirzepatide Dosing# Established FDA-approved dosing: Route : Once-weekly subcutaneous injection Starting dose : 2.5 mg weekly for 4 weeks Maintenance range : 5 mg, 10 mg, or 15 mg weekly Titration : 2.5 mg increments every 4 weeks to target dose Available formulations : Prefilled pens (Mounjaro/Zepbound) Tirzepatide's established titration protocol and prefilled pen delivery system offer practical advantages in clinical use