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In the RCTs, prebiotics showed similar clinical efficacy to mesalamine, and synbiotics, combined with probiotics and prebiotics, could also significantly decrease the CAI, the levels of intestinal mucosal inflammatory cytokines and fecal calprotectin, but not DAI [308,309,310,311,312]

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From these results we hypothesize that Dihexa-mediated protection relies, at least in part, on the activation of multiple downstream targets of the HGF/c-Met system (Akt-TOR and Ras-ERK)