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Gastrointestinal side effects of cancer treatments

The protective effect of SFN appears to be NRF2-dependent, as NRF2 deficiency exacerbated psoriasis-like symptoms, as well as the inflammatory response and abnormal proliferation of keratinocytes in the mice, and SFN had little therapeutic effect in the IMQ-modeled knockout mice

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Consequently, mitochondrial dysfunction has been identified as a central contributor to the onset and progression of various cardiovascular diseases, including HF, myocardial ischemia/reperfusion (I/R) injury, and atherosclerosis