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Keywords: roflumilast, methotrexate, hepatotoxicity, glutathione, malondialdehyde, tumor suppressor protein-53, interleukin 6, interleukin 1 Introduction Drug-induced liver toxicity is a major limitation of pharmacotherapy, which can lead to fatal adverse drug reactions and incidence of morbidity and mortality

Alam S, Laughton DL, Walding A, Wolstenholme AJ