Note that IGF1-LR3 and all IGF-1 derivatives do not promote cell enlargement (hypertrophy), but rather promote cell division and proliferation (hyperplasia)
"I typically recommend meeting protein requirements (many people fall short of this, especially as they age), choosing mostly plant-based sources of protein (these tend to not have the same associations with cancer and mortality), and not going overboard with protein (the goal is optimal, not excess!)." For people who work out and are trying to build or maintain lean muscle, the general consensus is to aim for up to 0.7 grams of protein per pound of body weight, per a 2018 report in the British Journal of Sports Medicine
While there is a multitude of affected cellular processes, these are likely a consequence of the initial insult, as the cause of SCA3 is uniquely a mutation in the ATXN3 gene
Theranostics 10(11):51075119 Cheng ZJ, Miao DL, Su QY et al (2019) THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism