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Certain flavonoids can even promote neuronal recovery: fisetin, quercetin, luteolin, and others have been observed to induce neurite outgrowth and synaptic marker expression, suggesting a capacity to support neural regeneration, although this requires continuous presence of the compounds and appears dose-dependent (9)

The mechanism involves suppression of reactive oxygen species (ROS) that the enteric nervous system uses to trigger peristaltic contractions, combined with microbiome shifts away from butyrate-producing bacteria

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