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Trimetallic Pt-Pd-Au alloy nanozymes for multimodal synergistic therapy to overcome deep-seated drug-resistant infections via ROS cascade

They have exhibited a wide variety of biological activities for thousands of years, including targeting mitochondrial dysfunction ( 2 Mitochondrial dysfunctions in kidney diseases 2.1 Mitochondrial homeostasis imbalance Mitochondrial quality control (MQC) is an elaborate mechanism to maintain homeostasis, ensuring the enough numbers of functional mitochondria (Figure 1)