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Although there is no close relationship between plasma VPA concentrations and the severity of CNS toxicity [11, 86], patients who ingest more than 200 mg/kg VPA and/or have plasma concentrations greater than 180 g/ml usually develop severe CNS depression

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Therefore, the study of glutathione is an important and extensive field of research that demands further examination to develop new prevention strategies and even therapies for many age-related diseases