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The histological lung sections and lung inflammation scores of the smoke-exposed mice confirmed pulmonary inflammation with perivascular and peribronchial cellular infiltrates, which has also been demonstrated in other in vivo studies [62, 63]

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Nicotine dependence can be assessed by questionnaires, for example the Fagerstrm test for nicotine dependence (Heatherton et al

Increased access to a significant proportion of Group cash flows provides further support to the Companys continued commitment to a dividend payout ratio of at least 65% and a strong financial profile, targeting a solid investment grade credit rating through progressive deleveraging