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The dermal papilla model that has generated the optimism is a screening tool whose very sensitivity means many hopefuls pass it and later fail in people

Certain enzymes are uniquely associated with bacterial cell walls or metabolic pathways and are absent or expressed at negligible levels in healthy microbiota

Published in Diabetologia (Blher and colleagues, NCT04153929), this Phase 2 trial randomized 413 adults with type 2 diabetes on background metformin to survodutide across several once-weekly or twice-weekly dose groups, to placebo, or to open-label semaglutide up to 1.0 mg once weekly