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Within 24 h of parturition, litters were culled to a maximum of 10 offspring and pups were weighed and randomly assigned a study ID and treatment group

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Conditions that prolong meconium passage (e.g., Hirschsprungs disease, meconium ileus, meconium plug syndrome) are associated with hyperbilirubinemia, presumably by allowing more time for intestinal bilirubin absorption