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Measurements of serum vitamin B 12 may not reliably detect deficiency, and measurement of serum homocysteine and/or methylmalonic acid should be used to confirm deficiency in asymptomatic high-risk patients with low normal levels of vitamin B 12

Oral B12 is most effective for people who: Follow a diet that includes plants Experience mild symptoms Need daily support to stay healthy Like taking supplements at home Do not have absorption problems The American Academy of Family Physicians explains that taking B12 works well to treat mild issues and for general supplementation, provided there are no absorption problems