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Simon A, Wegrowski Y, Bontemps Y, Maquart FX: Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+)

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These findings position neutrophil ferroptosisorchestrated by GPX4as a mechanistic bridge between iron dyshomeostasis and loss of self-tolerance in SLE, offering a rationale for therapeutic strategies targeting neutrophil redox resilience or iron chelation in autoimmune disease

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Catalytic Residues Roles Chemical Components ingold: aromatic unimolecular elimination by the conjugate base, hydride transfer, ingold: aromatic bimolecular nucleophilic addition, cofactor used, intermediate formation, overall product formed, overall reactant used, rate-determining step Step 2

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