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In this connection, the toxic profile of tobacco mainstream smoke was characterized in different studies (114, 115), which makes it possible to investigate the impact of some of these chemicals on the complement system, using curated databases such as the comparative toxicogenomic database (CTD) to delineate possible impacted pathways (116)

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2 Materials and methods 2.1 Setting and subjects A population-based survey was conducted from October to December 2021 in 235 kindergartens in the Longhua District of Shenzhen, China, with a total of 67,324 child-mother dyads recruited