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Together with evidence that the activation pattern of Nrf2 is rather short-lived but can be re-activated by repeated exposure, we can now understand a manner by which this pathway is persistently activated through chronic, daily exposure to cigarette smoke (and other environment toxins) leading to selection for cells and tumors predisposed toward chemoradiotherapy resistance

And he explained to me the whole thing and how unique it is

II Just a few months later, from a chair at his kitchen table, McMichael lamented his worsening condition

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