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Disruption of gut microbiota homeostasis is recognized as a key initial event that compromises intestinal barrier integrity, facilitating toxin translocation to the liver and subsequent effects on hepatic function and hypothalamic hormonal regulation

The more the child strains the more inflammation is perpetuated anorectal manometry, where the pressures of the anal sphincter muscles and the neural reflexes are measured can be carried out to find out if this is an issue

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