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Joint pain developing after starting B12 may reflect: Pre-existing musculoskeletal conditions becoming more noticeable Concurrent inflammatory or degenerative joint disease Reactions to excipients in certain formulations The natural course of an underlying condition If you experience persistent or worsening joint symptoms after beginning B12 supplementation, it is advisable to consult your GP or healthcare provider

Exendin-4, a glucagon-like peptide-1 receptor agonist, prevents osteopenia by promoting bone formation and suppressing bone resorption in aged ovariectomized rats

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The authors noted that this proliferation-inhibiting effect could have potential utility in anti-tumor applications, though further studies are needed to confirm its relevance in oncology contexts [43]