By binding with KEAP1, DPP9 promotes the stability of NRF2 and overcomes oxidative stress, and the accumulation of DPP9 can lead to the hyperactivation of the NRF2 pathway and inhibit ferroptosis, thereby driving ccRCC development and sorafenib resistance ( 3.3 Ferroptosis-associated lncRNAs in ccRCC Long non-coding RNAs (lncRNAs) are longer than 200 nucleotides, lack protein translation ability, and are expressed specifically in some tumor tissues ( The expression patterns of FRIncRNAs can be used to predict prognoses, and a risk model constructed using patient-specific FRlncRNAs has shown good diagnostic and prognostic value ( 3.4 Ferroptosis-associated genes in pRCC and chRCC As a key regulator of ferroptosis, SLC7A11 is up-regulated in ccRCC, chRCC, and pRCC, and its overexpression is associated with their poor prognosis and immune cell infiltration ( GCLC, HSBP1 and ACSF2 are independent prognostic FRGs in pRCC ( For chRCC, targetable pathways for innate lymphoid cell/IL-15 and cysteine homeostasis/ferroptosis have recently been discovered ( 4 Treatment of RCC 4.1 Targeted therapy and ferroptosis ccRCC is the most common type of kidney tumor, and traditional treatment methods for it include surgical resection, chemotherapy, and radiation therapy ( Crosstalk between different cell death pathways may also be related to resistance to targeted therapy, and the induction of different types of cell death, such as ferroptosis, through targeted therapy has become a new strategy in kidney cancer treatment ( Activation of ferroptosis by IL-6 is may provide a new strategy for the treatment of advanced RCC and new ideas for TKIs resistance (150)
A metabolic phenotype (strong insulin resistance, weight gain, elevated fasting insulin) is most likely to benefit from GLP-1 therapy
Kidney Int 49 : 13041313 Buonocore G, Perrone S, Longini M, Terzuoli L, Bracci R 2000 Total hydroperoxide and advanced oxidation protein products in preterm hypoxic babies
Optimization of spore production in Bacillus coagulans using response surface methodology approach
