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Furthermore, we found that LTR had significant increases in serine and inosine, which are required for optimal T cell proliferation, enhanced adoptive immunotherapy, and can reverse CAR T cell exhaustion in preclinical models 15,16 , as well as lactic acid, which preclinically improves adoptive immunotherapy 17 and might be related to increased LDHA expression seen in this group (Fig

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Endocrine 84:309319 Nappi A, Miro C, Cicatiello AG, et al (2025) The thyroid hormone activating enzyme, DIO2, is a potential pan-cancer biomarker and immunotherapy target

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