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While some studies suggest that vaping may expose users to fewer toxic substances than traditional smoking, evidence indicates that e-cigarette aerosols still contain harmful chemicals, including formaldehyde and ultrafine particles, which can cause airway inflammation, oxidative stress, and lung tissue damage factors that contribute to respiratory disease progression, including COPD 20

Indian J Dent Res

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The accuracy of The PLCO m2012 model alone, which predicts a 6-year risk of lung cancer among current or former smoker based on individual characteristics, was significantly lower, at 80%