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Given the known pleiotropy of ETC inhibition (for example, AMPK activation and ATP depletion), these approaches will probably require context-aware deployment rather than broad application

2. Pathways linked to cell timing

Agencies will also be encouraged to clarify requirements for Phase III eligibility, reinforcing a broader push to support commercialization beyond Phase II

Front Nutr 7:570344 Thi HHP, Thi TVP, Huynh NP, Doan V, Onoda S, Nguyen TL (2022) Therapeutic effect of heat-killed Lactobacillus plantarum L-137 on the gut health and growth of broilers