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This suggests that the higher rates of glucuronidation associated with this UGT1 polymorphism protect against paracetamol hepatotoxicity by decreasing the fractional proportion of paracetamol available for oxidation

Last reviewed: June 8, 2026 Last updated: June 8, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Atherosclerosis 137:S61S64 Zejaczkowska MK-KR, Leppert W, Wrzosek A, Mika J, Wordliczek J (2019) Mechanisms of chemotherapy-induced peripheral neuropathy

however, wild-type mice supplemented with selenium survive normally